ALS amyotrophic lateral sclerosis AMPA α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid GABA γ-aminobutyric acid NMDA N-methyl-D-aspartate PD Parkinson’s disease
نویسندگان
چکیده
Addresses *Howard Hughes Medical Institute and Baylor College of Medicine, One Baylor Plaza MS225, Houston, Texas 77030, USA; e-mail: [email protected] †Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA; e-mail: [email protected] ‡Department of Neurology, Washington University School of Medicine, Center for the Study of Nervous System Injury, 660 South Euclid Avenue, St Louis, Missouri 63110, USA; e-mail: [email protected] Correspondence: Fred H Gage
منابع مشابه
Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex.
In the rat, subunits of the glutamate receptor family fall into three pharmacologically distinct groups: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid preferring receptors (Glu R1-4), kainate preferring receptors (Glu R5-7, KA 1, KA 2), and N-methyl-D-aspartate preferring receptors (NMDA R1, NMDA R2A-2D). In the present study, we demonstrate immunocytochemically that the majority of...
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Academic Dissertation To be presented for public criticism, with the permission of the Faculty of Science of the (1998) Disulfide bonding and cysteine accessibility in the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors. receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism ...
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Excitatory aminoacids (EAAs) are stored in glutamatergic neurons and related into synaptic cleft, where they can activate inotropic or metabotropic receptors. Their action ends due to transport mechanisms performed by EAAT transporters (EAAT1/GLAST, EAAT2/GLT1, EAAT3/EAAC1, and EAAT4 or EAAT5). Glutamate neurotoxicity has been described in several neurodegenerative diseases such as Alzheimer’s ...
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BACKGROUND The minimum alveolar concentration is determined in the spinal cord rather than in the brain. Xenon inhibits glutamatergic excitatory synaptic transmission in the dorsal horn neurons. However, its actions in the ventral horn neurons have not been investigated. METHODS The effects of 50 or 75% xenon on excitatory and inhibitory synaptic transmission were examined in the spinal lamin...
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Abbreviations: 6-hydroxydopamine, (6-OHDA); adeno-associated virus, (AAV); Alzheimer’s disease, (AD); amyotrophic lateral sclerosis, (ALS); brain derived neurotrophic factor, (BDNF); Core Program for Intracerebral Transplantations, (CAPIT); central nervous system, (CNS); ciliary neurotrophic factor, (CNTF); cerebrospinal fluid, (CSF); dopamine, dopaminergic, (DA); deoxyribonucleic acid, (DNA); ...
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